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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TH
All Species:
16.97
Human Site:
Y255
Identified Species:
28.72
UniProt:
P07101
Number Species:
13
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P07101
NP_000351.2
528
58600
Y255
D
P
I
P
R
V
E
Y
T
A
E
E
I
A
T
Chimpanzee
Pan troglodytes
XP_508221
618
67613
Y345
D
P
I
P
R
V
E
Y
T
A
E
E
I
A
T
Rhesus Macaque
Macaca mulatta
Q2HZ26
490
56076
S228
G
V
V
F
R
E
L
S
K
L
Y
P
T
H
A
Dog
Lupus familis
XP_855547
495
55650
E232
E
E
I
A
T
W
K
E
V
Y
T
T
L
K
S
Cat
Felis silvestris
Mouse
Mus musculus
P24529
498
55975
T232
Y
T
K
E
E
I
A
T
W
K
E
V
Y
A
T
Rat
Rattus norvegicus
P04177
498
55948
A231
E
Y
T
A
E
E
I
A
T
W
K
E
V
Y
V
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001507458
568
65241
Y295
Q
P
I
P
R
I
E
Y
T
E
E
E
K
K
T
Chicken
Gallus gallus
P70080
445
51121
N183
G
T
V
Y
R
E
L
N
K
L
Y
P
T
H
A
Frog
Xenopus laevis
Q92142
481
55388
N219
G
T
V
F
R
E
L
N
K
L
Y
P
T
H
A
Zebra Danio
Brachydanio rerio
NP_571224
489
55584
V227
E
I
G
T
W
R
E
V
Y
S
T
L
R
D
L
Tiger Blowfish
Takifugu rubipres
NP_001027874
476
54285
R214
S
T
W
R
E
V
Y
R
Q
L
R
S
V
Y
P
Fruit Fly
Dros. melanogaster
P18459
579
65977
Y303
D
P
I
P
F
I
D
Y
S
D
V
E
V
K
T
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
P90925
457
52111
T195
R
T
V
Y
N
E
L
T
V
M
Y
P
K
N
A
Sea Urchin
Strong. purpuratus
XP_786206
522
59629
Y249
Q
P
I
P
R
V
E
Y
T
D
D
E
L
R
T
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
82.1
43.1
84.2
N.A.
83.3
84.2
N.A.
45
43.7
42.9
65.1
51.8
43.1
N.A.
40.7
46.7
Protein Similarity:
100
83.6
60
87.5
N.A.
86.9
87.8
N.A.
60.3
58.7
60.2
77.6
66.8
61.4
N.A.
59.2
65.7
P-Site Identity:
100
100
6.6
6.6
N.A.
20
13.3
N.A.
66.6
6.6
6.6
6.6
6.6
46.6
N.A.
0
66.6
P-Site Similarity:
100
100
13.3
33.3
N.A.
26.6
33.3
N.A.
73.3
13.3
13.3
20
13.3
73.3
N.A.
6.6
80
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
15
0
0
8
8
0
15
0
0
0
22
29
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
22
0
0
0
0
0
8
0
0
15
8
0
0
8
0
% D
% Glu:
22
8
0
8
22
36
36
8
0
8
29
43
0
0
0
% E
% Phe:
0
0
0
15
8
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
22
0
8
0
0
0
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
22
0
% H
% Ile:
0
8
43
0
0
22
8
0
0
0
0
0
15
0
0
% I
% Lys:
0
0
8
0
0
0
8
0
22
8
8
0
15
22
0
% K
% Leu:
0
0
0
0
0
0
29
0
0
29
0
8
15
0
8
% L
% Met:
0
0
0
0
0
0
0
0
0
8
0
0
0
0
0
% M
% Asn:
0
0
0
0
8
0
0
15
0
0
0
0
0
8
0
% N
% Pro:
0
36
0
36
0
0
0
0
0
0
0
29
0
0
8
% P
% Gln:
15
0
0
0
0
0
0
0
8
0
0
0
0
0
0
% Q
% Arg:
8
0
0
8
50
8
0
8
0
0
8
0
8
8
0
% R
% Ser:
8
0
0
0
0
0
0
8
8
8
0
8
0
0
8
% S
% Thr:
0
36
8
8
8
0
0
15
36
0
15
8
22
0
43
% T
% Val:
0
8
29
0
0
29
0
8
15
0
8
8
22
0
8
% V
% Trp:
0
0
8
0
8
8
0
0
8
8
0
0
0
0
0
% W
% Tyr:
8
8
0
15
0
0
8
36
8
8
29
0
8
15
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _